Distribution of TFF peptides in corneal disease and pterygium.

  title={Distribution of TFF peptides in corneal disease and pterygium.},
  author={Philipp Steven and Georg Sch{\"a}fer and Bernard N{\"o}lle and Margitta Hinz and Werner Hoffmann and Friedrich Paulsen},
  volume={25 5},
The central cornea of 10 cadavers and 33 patients suffering from keratoconus, herpetic keratitis, Fuchs' dystrophy and pterygium were analysed focusing on the expression of TFF peptides by means of reverse transcription polymerase chain reaction and immunohistochemistry. TFF1 and TFF3 transcripts were detected in healthy corneae as well as in pterygia. Only TFF3 mRNA was transcribed in keratoconus, Fuchs' dystrophy and herpetic keratitis. Immunohistochemistry revealed absence of all three TFF… CONTINUE READING