Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes

@article{Wang2005DistributionOS,
  title={Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes},
  author={Jinhua Wang and Philip J. Smith and Adrian R. Krainer and Michael Q Zhang},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={5053 - 5062}
}
Exonic splicing enhancers (ESEs) are pre-mRNA cis-acting elements required for splice-site recognition. We previously developed a web-based program called ESEfinder that scores any sequence for the presence of ESE motifs recognized by the human SR proteins SF2/ASF, SRp40, SRp55 and SC35 (http://rulai.cshl.edu/tools/ESE/). Using ESEfinder, we have undertaken a large-scale analysis of ESE motif distribution in human protein-coding genes. Significantly higher frequencies of ESE motifs were… CONTINUE READING
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