Distribution of Rhesus Blood Group System in the French Basques: A Reappraisal Using the Allele-Specific Primers PCR Method

@article{Touinssi2005DistributionOR,
  title={Distribution of Rhesus Blood Group System in the French Basques: A Reappraisal Using the Allele-Specific Primers PCR Method},
  author={Mhammed Touinssi and Jacques Chiaroni and Anna Degioanni and Philippe de Micco and Olivier Dutour and Fr{\'e}deric Bauduer},
  journal={Human Heredity},
  year={2005},
  volume={58},
  pages={69 - 72}
}
Objectives: To determine for the first time using PCR the distribution of Rhesus (Rh) blood group in French Basques and compare these results with those obtained by serology in the same sample and in the historical series from various Basque subgroups. Methods: Rh polymorphism was determined in a sample of 127 autochthonous French Basques using allele-specific primers (ASP) PCR and traditional serological technique. Statistical comparisons were performed between both techniques and with the… 

Tables from this paper

DNA‐based typing of Kell, Kidd, MNS, Dombrock, Colton, and Yt blood group systems in the French Basques

The frequency of less‐explored‐ or still noninvestigated blood groups using DNA‐based assays and interpreted these data in the view of population genetics are evaluated and constitute additional data to be included in the chapter of Basque biological anthropology.

Red cell groups and Basque population(s): From anthropology to public health.

  • F. Bauduer
  • Biology
    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
  • 2019

Is the management of Rh-Rh incompatibility with noninvasive fetal Rh genotyping for targeted prophylaxis cost-effective in the Turkish population?

Unless the cost of noninvasive fetal Rh genotyping is reduced, a universal approach of anti-D immune globulin prophylaxis is more cost-effective than nonin invasive determination of fetal Rh Genotyping with targeted prophYLaxis.

Evolutionary genetics of the human Rh blood group system

This study used new molecular and genomic data generated from four HapMap population samples to test the idea that positive selection for an as-of-yet unknown fitness benefit of the RHD deletion may have offset the otherwise negative fitness effects of hemolytic disease of the newborn, and found no evidence that positive natural selection affected the frequency of theRHD deletion.

Sequence diversity of the Rh blood group system in Basques

Haplotype analyses of D/d, E/e, and C/c variants confirmed an association between the RhC allele, previously suggested to be under positive selection, and the RhD positive variant in non-sub-Saharan populations, including Basques.

Prevalence of RhD status and clinical application of non-invasive prenatal determination of fetal RHD in maternal plasma: a 5 year experience in Cyprus

Fetal RHD genotyping can be accurately determined using cffDNA from maternal plasma and the implementation of the test has eliminated all use of unnecessary anti-D and reduced the total use ofAnti-D by 25.3 % while achieving appropriate management of the RhD negative pregnancies.

References

SHOWING 1-10 OF 17 REFERENCES

A HEMATOLOGICAL APPROACH TO BASQUE ISOLATION IN TWO FRENCH BASQUE VILLAGES *

The Basques of northwest Spain and southwest France are a longrecognized but, until recently, ill-defined isolate that has exhibited one after another a series of blood group allele frequencies so different from that of other European populations that they are now generally regarded as a genetic isolate.

The Distribution of the Human Blood Groups and other Polymorphisms

The blood groups have been a trail blazer for the study of human polymorphism, and this book provides a data bank in a single volume which can be consulted at short notice in most larger laboratories.

Genetic polymorphisms of the Basques from Gipuzkoa: genetic heterogeneity of the Basque population.

The results of this study indicate that the Basque population of Gipuzkoa presents certain differential values with respect to other Basque series, such as maximum values for RH*cde, AK*2 and PGM1*2+ and minimum for PGM 1*1-, while the remaining alleles are located within the range of values found in theBasque population to date.

Specificity and sensitivity of RHD genotyping methods by PCR‐based DNA amplification

Comparing the sensitivity and specificity of four PCR methods of RHD gene detection using different sets of primers located in the regions of highest divergence between the RHD and RHCE genes found a full correlation between the predicted genotype and observed phenotype at birth of 92 infants.

Structuring the Genetic Heterogeneity of the Basque Population: A View from Classical Polymorphisms

Analysis of classical polymorphisms in over 2000 autochthonous individuals suggests that allele distribution is geographically patterned in the Basque Country and the gene flow tends toward the coast.

DNA polymorphisms detect ancient barriers to gene flow in Basques.

The results indicate that the populations of the Basque Country are genetically close to other neighboring populations, such as that of Aragon, which may indicate an outgoing gene flow from the Basques area down the River Ebro towards the Mediterranean seaboard.

PCR‐based determination of Rhc and RhE status of fetuses at risk of Rhc and RhE haemolytic disease

Polymerase chain reaction assays which detect the presence of the Rhc alleles in amniotic cells by the use of allele‐specific primers (ASP) are reported here and it is expected that such determination will help in the management of pregnancies at risk of Rhc haemolytic disease.

The Blood Groups of The Spanish Basques

It is shown that the Basques have the lowest frequency of Rh-negatives in Europe, and the frequency of the CDe chromosome to be high and that of cDE to be the lowest recorded in Europe.

The "Basqueness" of the Basques of Alava: a reappraisal from a multidisciplinary perspective.

The data obtained in this genetic study and those from archaeology, linguistics, ethnography, and skeletal biology suggest that within the "Basque population" there may be at least two distinct groups: an "Atlantic" group and a "Mediterranean" one, divided mainly by the watershed.

Y genetic data support the Neolithic demic diffusion model

A statistical framework is applied to obtain direct estimates of the relative contributions of European Palaeolithic hunter-gatherers and migrant Near Eastern Neolithic farmers, and argues that the demic diffusion model introduced by Ammerman and Cavalli-Sforza captures the major features of this dramatic episode in European prehistory.