Distribution of Peyer's Patches in the Distal Ileum

  title={Distribution of Peyer's Patches in the Distal Ileum},
  author={H. V. Van Kruiningen and A. West and B. Freda and Kimberly A Holmes},
  journal={Inflammatory Bowel Diseases},
Background and AimsPeyer's patches play a major role in intestinal immunity, are portals of entry for significant pathogens, and may be important in Crohn's disease. Whereas their microscopic anatomy and immune function are well described, surprisingly little is known of their macroscopic anatomy and distribution. Our aim was to assess their number, area, and distribution in the normal distal ileum, with particular reference to patient age. MethodsDistal ilea (200 cm) obtained at autopsy from… Expand
Postmortem morphology and viability of human Peyer’s Patches in distal ileum: A technical note
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Current knowledge on the epithelial phenotype of the human FAE, and changes of the FAE and M cells in intestinal inflammation, are reviewed, leading to a hypothesis of the role of theFAE andM cells in the pathogenesis of CD. Expand
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This short review will discuss barrier dysfunction and bacteria in the context of ileal Crohn's disease, and how the FAE might be the site of initial inflammation. Expand
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Number, size, and distribution of Peyer's patches in the human small intestine
The present study was undertaken to find out how many patches there are in the normal human gut and to investigate what happens to them before and after birth. Expand
The role of Peyer's patches in the age-related incidence of Crohn's disease.
When the age-related incidence of Crohn's disease was plotted for all countries from which such data were available, the peaks of greatest case frequency occurred at ages 15 to 25 years and paralleled a similar peak representing the number of Peyer's patches as a function of age, suggesting that Crohn’s disease may develop as an inflammatory process specifically targeting these important lymphoid structures. Expand
The pathology of Yersinia enterocolitica ileocolitis
The terminal ileum and proximal colon were resected in two children presenting with fever and right lower quadrant abdominal pain and resulted in thickened, erythematous distal ilcum mistaken at surgery for Crohn's disease, which was recovered from operative cultures of both the specimens. Expand
REVIEW: Peyer's patches
The function of Peyer's patches as antigenic sampling sites involves the complex interplay of a variety of mechanisms that aim to recognize luminal antigens, induce an immunological response andExpand
Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study.
  • R. Owen
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Transport of intestinal luminal material by M cells with subsequent uptake by lymphocytes provides a specific route for antigen uptake into the intestinal lymphoid system. Expand
Histopathologic spectrum of regional enteritis and ulcerative colitis.
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A review was conducted to heighten awareness of pseud oneoplasms, to help differentiate among the various types of pseudoneoplasm, and to help distinguish pseudOneoplasms from malignancies. Expand
Expanding the role of Peyer's patches in B-cell ontogeny.
Age-independent mean area of Peyer's patch tissue in each 25 cm segment of ileum from the ileocecal valve proximally