Distribution of Pethidine and Chlorpromazine in Maternal, Foetal and Neonatal Biological Fluids

@article{Odonoghue1971DistributionOP,
  title={Distribution of Pethidine and Chlorpromazine in Maternal, Foetal and Neonatal Biological Fluids},
  author={S O'donoghue},
  journal={Nature},
  year={1971},
  volume={229},
  pages={124-125}
}
EVIDENCE for placental transfer of drugs was obtained in 1885 when Preyer1 observed mydriasis in newborns whose mothers had received belladonna during labour. Since then analgesia has been recognized as a considerable problem in obstetrics, for the opiates and other allied and synthetic narcotics administered during labour have respiratory depressant effects on the foetus. While the search for optimum analgesia with minimum adverse effects on the foetus continues, pethidine, first introduced in… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS