Distribution of KRAS, DDR2, and TP53 gene mutations in lung cancer: An analysis of Iranian patients

@inproceedings{Fathi2018DistributionOK,
  title={Distribution of KRAS, DDR2, and TP53 gene mutations in lung cancer: An analysis of Iranian patients},
  author={Zahra Fathi and Seyed Ali Javad Mousavi and Raheleh Roudi and Farideh Ghazi},
  booktitle={PloS one},
  year={2018}
}
PURPOSE Lung cancer is the deadliest known cancer in the world, with the highest number of mutations in proto-oncogenes and tumor suppressor genes. Therefore, this study was conducted to determine the status of hotspot regions in DDR2 and KRAS genes for the first time, as well as in TP53 gene, in lung cancer patients within the Iranian population. EXPERIMENTAL DESIGN The mutations in exon 2 of KRAS, exon 18 of DDR2, and exons 5-6 of TP53 genes were screened in lung cancer samples, including… CONTINUE READING
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Molecular epidemiology of lung cancer in Iran : implications for drug development and cancer prevention

Z Fathi, NL Syn, Zhou J-G, R Roudi
  • Journal of Human Genetics
  • 2018

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