Distribution of IGF receptors in the plasma membrane of proximal tubular cells.

  title={Distribution of IGF receptors in the plasma membrane of proximal tubular cells.},
  author={Marc R. Hammerman and Sharon A. Rogers},
  journal={The American journal of physiology},
  volume={253 5 Pt 2},
To characterize the distribution of receptors for insulin-like growth factors I and II (IGF I and II) in the plasma membrane of the renal proximal tubular cell, we measured binding of 125I-labeled IGF I and 125I-labeled IGF II to proximal tubular basolateral and brush-border membranes and characterized IGF I-stimulated phosphorylation of detergent-solubilized membranes. 125I-IGF I bound primarily to a 135,000 relative molecular weight (Mr) protein and IGF II to a 260,000 Mr protein in isolated… CONTINUE READING

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