Distribution of HLA class 1 antigens in normal human tissue and in mammary cancer.

  title={Distribution of HLA class 1 antigens in normal human tissue and in mammary cancer.},
  author={K. A. Fleming and Andrew Mcmichael and Julia Morton and Jeffery C. Woods and J O Mcgee},
  journal={Journal of clinical pathology},
  volume={34 7},
With a monoclonal antibody which reacts with all HLA class 1 antigens it was found that these antigens are not uniformly distributed in all nucleated cells. Rather HLA class 1 antigens are restricted in their distribution to lymphoid cells, endothelial cells of small vessels, and certain epithelia including mammary duct cells. These antigens were not detected on hepatocytes, specialised cells of the central nervous system, or on the tumour cells of 8 out of 17 human mammary cancers. Given the… CONTINUE READING
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