Distribution of Glutamate Transporter Subtypes During Human Brain Development

  title={Distribution of Glutamate Transporter Subtypes During Human Brain Development},
  author={O. Bar-Peled and H. Benhur and A. Biegon and Y. Groner and S. Dewhurst and A. Furuta and J. Rothstein},
  journal={Journal of Neurochemistry},
  • O. Bar-Peled, H. Benhur, +4 authors J. Rothstein
  • Published 1997
  • Biology, Medicine
  • Journal of Neurochemistry
  • Abstract: In the mature brain, removal of glutamate from the synaptic cleft plays an important role in the maintenance of subtoxic levels of glutamate. This requirement is handled by a family of glutamate transporters, EAAT1, EAAT2, EAAT3, and EAAT4. Due to the involvement of glutamate also in neuronal development, it is believed that glutamate transport plays a role in developmental processes as well. Therefore, we have used immunohistochemical and immunoblot analysis to determine the… CONTINUE READING
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