Distribution of Glutamate Transporter Subtypes During Human Brain Development

@article{BarPeled1997DistributionOG,
  title={Distribution of Glutamate Transporter Subtypes During Human Brain Development},
  author={Osnat Bar-Peled and Herzl Ben‐Hur and Anat Biegon and Yoram Groner and Susan A. Dewhurst and Akiko Furuta and Jeffrey D. Rothstein},
  journal={Journal of Neurochemistry},
  year={1997},
  volume={69}
}
Abstract: In the mature brain, removal of glutamate from the synaptic cleft plays an important role in the maintenance of subtoxic levels of glutamate. This requirement is handled by a family of glutamate transporters, EAAT1, EAAT2, EAAT3, and EAAT4. Due to the involvement of glutamate also in neuronal development, it is believed that glutamate transport plays a role in developmental processes as well. Therefore, we have used immunohistochemical and immunoblot analysis to determine the… 
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149 Citations

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The expression of EAAT2 in pyramidal neurons during human brain development may contribute to cortical vulnerability to excitotoxicity during the critical period for perinatal hypoxic–ischemic encephalopathy.
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The amino acid transporters play pivotal roles in the process of delayed neuronal death in the hippocampal CA1 field of gerbils with transient forebrain ischemia, suggested.
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Role of Excitatory Amino Acid Transporter‐2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics
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The potential utility of the EAAT2 promoter is emphasized for developing both low and high throughput screening assays to identify novel small molecule regulators of glutamate transport with potential to ameliorate pathological changes occurring during and causing neurodegeneration.
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TLDR
These findings support the hypothesis of glutamatergic dysfunction in schizophrenia and suggest that molecules other than glutamate receptors are abnormally expressed in glutamatersgic synapses in this illness.
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References

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