• Biology, Medicine
  • Published in Journal of cell science 2000

Distribution of GPI-anchored proteins in the protozoan parasite Leishmania, based on an improved ultrastructural description using high-pressure frozen cells.

@article{Weise2000DistributionOG,
  title={Distribution of GPI-anchored proteins in the protozoan parasite Leishmania, based on an improved ultrastructural description using high-pressure frozen cells.},
  author={Frank-J. Weise and York Stierhof and Carsten K{\"u}hn and Martin Wiese and Peter Overath},
  journal={Journal of cell science},
  year={2000},
  volume={113 Pt 24},
  pages={
          4587-603
        }
}
The cellular distribution of two glycosyl-phosphatidylinositol (GPI)-anchored proteins and a trans-membrane protein and the compartments involved in their trafficking were investigated in the insect stage of Leishmania mexicana, which belongs to the phylogenetically old protozoan family Trypanosomatidae. Electron microscopy of sections from high-pressure frozen and freeze-substituted cells allowed a detailed description of exo- and endocytic structures located in the vesicle-rich, densely… CONTINUE READING

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