Distribution of GABA receptor ρ subunit transcripts in the rat brain

@article{Wegelius1998DistributionOG,
  title={Distribution of GABA receptor $\rho$ subunit transcripts in the rat brain},
  author={Katri Wegelius and Michael Pasternack and Jukka O. Hiltunen and Claudio Rivera and Kai Kaila and Mart Saarma and Mati Reeben},
  journal={European Journal of Neuroscience},
  year={1998},
  volume={10}
}
The γ‐aminobutyric acid (GABA) receptor ρ subunits recently cloned from rat and human retina are thought to form GABA receptor channels belonging to a pharmacologically distinct receptor class, termed GABAC. In this work we have examined the distribution of ρ1, ρ2 and ρ3 subunits, and found expression of all three transcripts in several regions of the rat nervous system. 

Distribution and function of GABA receptor ρ subunits in the rat nervous system

The ρ 1 GABA receptor cloned from rat retina is down-modulated by protons. sensitivities of human and rat ρ 1 GABA receptors to extracellular pH.

GABAC receptor ρ subunits are heterogeneously expressed in the human CNS and form homo‐ and heterooligomers with distinct physical properties

TLDR
The results indicate that the presence of both ρ subunits enables the formation of heterooligomeric receptors with physical properties distinct from homooligomers, thus increasing the diversity of GABAC receptors in the CNS.

γ‐Aminobutyric acidA ρ receptor subunits in the developing rat hippocampus

TLDR
The RT‐PCR approach was used to estimate the expression of γ‐aminobutyric acid (GABA)A ρ receptor subunits in the hippocampus of neonatal and adult rats, finding that the ρ1 and ρ2 products appeared to be developmentally regulated; they were found to be more pronounced in adulthood.

Interaction of GABA Receptor/Channel ρ1 and γ2 Subunit

TLDR
The results indicate that protein-protein and functional interactions can occur between the GABA A γ 2 subunit and the GABA C p, subunit, and the functional role of GABA receptor/channels in the brain, retina, and spinal cord is more diversified because of the possible assembly between theγ 2 sub unit and GABA C P 1 subunit.

Function of γ-Aminobutyric Acid Receptor/Channel ρ1 Subunits In Spinal Cord*

TLDR
Findings indicate that the GABA receptor/channel ρ1 subunit plays an important role in modulating spinal cord pain transmission functions in vivo.

Nitric oxide potentiation of the homomeric ρ1 GABAC receptor function

TLDR
This work examined whether GABAC receptor function can also be regulated by NO, which acts as a neuronal signal mediating physiological or pathological mechanisms.

An Update on GABAρ Receptors

The present review discusses the functional and molecular diversity of GABAρ receptors. These receptors were originally described in the mammalian retina, and their functional role in the visual

GABAC Receptors: A Molecular View

  • R. Enz
  • Biology, Chemistry
    Biological chemistry
  • 2001
TLDR
This review summarizes recent data in view of the molecular structure of GABAC receptors and presents new insights into the biological function of this protein in the retina.
...

References

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We used digoxigenin-labelled single strand DNA probes to examine the expression of the mRNA encoding gamma-aminobutyric acid receptor rho 3 subunit in sections of the adult rat retina. Transcript for

Expression of GABA Receptor ρ1 and ρ2 Subunits in the Retina and Brain of the Rat

TLDR
The results support the idea that ρ subunits are part of the GABAC receptor, and use of the polymerase chain reaction with reverse‐transcribed total RNA (RT‐PCR) from different brain tissues revealed that transcript for the ρ1 subunit was present in the retina only.

Identification of GABAA Receptor Subunits in Rat Retina: Cloning of the Rat GABAA Receptor ρ2‐Subunit cDNA

TLDR
The results support the hypothesis that bicuculline‐insensitive GABA channels in rat retina are comprised of ρ subunits, and two clones closely related to the human GABAAρ‐subunit class were obtained.

Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes.

TLDR
Compared the electrical and pharmacological properties of GABA receptors expressed by poly(A)+ RNA isolated from mammalian brain and retina, these results suggest that mammalian retina contains RNAs encoding GABA receptors with distinct pharmacology.

Immunocytochemical Localization of the GABACReceptor ρ Subunits in the Mammalian Retina

TLDR
Polyclonal antibodies against the N terminus of the rat ρ1 subunit were generated to study the distribution of GABAC receptors in the mammalian retina and showed the punctate immunofluorescence to colocalize with bipolar cell axon terminals.

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

  • G. CuttingL. Lu G. Uhl
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    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
Features are consistent with the identification of a GABA subunit, GABA rho 1, with prominent retinal expression that increases the diversity and tissue specificity of this ligand-gated ion-channel receptor family.