Distribution of GABA receptor ρ subunit transcripts in the rat brain

@article{Wegelius1998DistributionOG,
  title={Distribution of GABA receptor $\rho$ subunit transcripts in the rat brain},
  author={K. Wegelius and M. Pasternack and J. Hiltunen and C. Rivera and K. Kaila and M. Saarma and M. Reeben},
  journal={European Journal of Neuroscience},
  year={1998},
  volume={10}
}
The γ‐aminobutyric acid (GABA) receptor ρ subunits recently cloned from rat and human retina are thought to form GABA receptor channels belonging to a pharmacologically distinct receptor class, termed GABAC. In this work we have examined the distribution of ρ1, ρ2 and ρ3 subunits, and found expression of all three transcripts in several regions of the rat nervous system. 
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WE used digoxigenin-labelled single strand DNA probes to examine the expression of the mRNA encoding γ-aminobutyric acid receptor ρ3 subunit in sections of the adult rat retina. Transcript for the ρ3Expand
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We used digoxigenin-labelled single strand DNA probes to examine the expression of the mRNA encoding gamma-aminobutyric acid receptor rho 3 subunit in sections of the adult rat retina. Transcript forExpand
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The main result of the findings is that the antepituitary expresses mRNAs encoding alpha 4 and rho 1 GABA receptor subunits, believed to be constituents of benzodiazepine-insensitive GABAA and GABAC receptors in the CNS. Expand
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TLDR
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  • Medicine, Chemistry
  • Trends in Neurosciences
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TLDR
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TLDR
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TLDR
Polyclonal antibodies against the N terminus of the rat ρ1 subunit were generated to study the distribution of GABAC receptors in the mammalian retina and showed the punctate immunofluorescence to colocalize with bipolar cell axon terminals. Expand
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