Distribution of Foxp3-, CD4- and CD8-positive lymphocytic cells in benign and malignant prostate tissue.

  title={Distribution of Foxp3-, CD4- and CD8-positive lymphocytic cells in benign and malignant prostate tissue.},
  author={Alexander Valdman and Sara Jonmarker Jaraj and Eva Comperat and Fr{\'e}d{\'e}ric Charlotte and Morgan Roupr{\^e}t and Pavel Pisa and Lars Egevad},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={118 5},
Foxp3 is a transcription factor that inhibits antitumor immune response and is expressed in regulatory T cells (Tregs). High levels of Tregs have been reported in several human cancers. This study investigates the distribution of cells positive for Foxp3, CD4 and CD8 in benign prostatic tissues and prostatic carcinoma. Tissue microarrays were constructed from radical prostatectomy specimens of 36 patients. From each patient, six cores were taken: two cores from cancer, one from benign tissue of… CONTINUE READING

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