Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain

@inproceedings{Abe2013DistributionOD,
  title={Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain},
  author={Masao Abe and Shinichiro Ochi and Yoko Mori and Kiyohiro Yamazaki and Takashi Ishimaru and Yuta Yoshino and Ryuji Fukuhara and Satoshi Tanimukai and Seiji Matsuda and Shu-Ichi Ueno},
  booktitle={BMC Neuroscience},
  year={2013}
}
D-3-aminoisobutyrate, an intermediary product of thymine, is converted to 2-methyl-3-oxopropanoate using pyruvate as an amino acceptor by D-3-aminoisobutyrate-pyruvate aminotransferase (D-AIB AT; EC 2.6.1.40). A large amount of D-AIB AT is distributed in the kidney and liver; however, small amounts are found in the brain. Recently, D-AIB AT was reported to metabolize asymmetric dimethylarginine (ADMA) in vivo and was suggested to be an important enzyme for nitric oxide metabolism because ADMA… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

TL: Disorders of omega-amino acids in free and peptidelinked forms

CR Scriver, Perry
  • In The Metabolic Basis of Inherited Disease
  • 1989
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

The relationship of topographical memory performance to regional neurodegeneration in Alzheimer’s disease

G Pengas, G Williams, +6 authors J Nestor
  • Front Aging Neurosci 2012,
  • 2012
VIEW 1 EXCERPT

Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2008
VIEW 1 EXCERPT

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