Distribution of CRISPR spacer matches in viruses and plasmids of crenarchaeal acidothermophiles and implications for their inhibitory mechanism.

@article{Shah2009DistributionOC,
  title={Distribution of CRISPR spacer matches in viruses and plasmids of crenarchaeal acidothermophiles and implications for their inhibitory mechanism.},
  author={Shiraz A. Shah and Niels Richard Hansen and Roger A. Garrett},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 1},
  pages={23-8}
}
Transcripts from spacer sequences within chromosomal repeat clusters [CRISPRs (clusters of regularly interspaced palindromic repeats)] from archaea have been implicated in inhibiting or regulating the propagation of archaeal viruses and plasmids. For the crenarchaeal thermoacidophiles, the chromosomal spacers show a high level of matches ( approximately 30%) with viral or plasmid genomes. Moreover, their distribution along the virus/plasmid genomes, as well as their DNA strand specificity… CONTINUE READING
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