Distribution of CCR5 genotypes and HLA Class I B alleles in HIV-1 infected and uninfected injecting drug users from Rio de Janeiro, Brazil.

@article{Teixeira2009DistributionOC,
  title={Distribution of CCR5 genotypes and HLA Class I B alleles in HIV-1 infected and uninfected injecting drug users from Rio de Janeiro, Brazil.},
  author={Sylvia Lopes Maia Teixeira and Francisco I. Bastos and Mariana de Andrea Vilas Boas Hacker and Mariza Gonçalves Morgado},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2009},
  volume={9 4},
  pages={638-42}
}
Host genetic factors play an important role in the HIV epidemic dynamics, and have been considered in studies assessing susceptibility/resistance to HIV-1 infection as well as clinical evolution. Class I and Class II HLA alleles have been associated with the heterogeneity of HIV-1 infection susceptibility, as protective or risk factors for HIV-1 transmission. Moreover, a 32-base pair deletion in the HIV-1 CCR5 gene-coding region confers resistance to HIV-1 infection in homozygous individuals… CONTINUE READING
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Infection, Genetics and Evolution

  • S.L.M. Teixeira
  • 2009

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