Distribution of 3α-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans

@article{Khanna1995DistributionO3,
  title={Distribution of 3$\alpha$-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans},
  author={Marilyn Khanna and Ke-nan Qin and K. -C. Cheng},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1995},
  volume={53},
  pages={41-46}
}
  • M. Khanna, K. Qin, K. Cheng
  • Published 1995
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
3 alpha-Hydroxysteroid dehydrogenase in the brain is responsible for production of neuroactive tetrahydrosteroids that interact with the major inhibitory gamma-aminobutyric acid receptor complexes. Distribution of 3 alpha-hydroxysteroid dehydrogenase in different regions of the brain in rats was evaluated by activity assay and by Western immunoblotting using a monoclonal antibody against liver 3 alpha-hydroxysteroid dehydrogenase as the probe. The olfactory bulb was found to contain the highest… Expand
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