Distribution of α 1a-, α 1b- and α 1d-adrenergic receptor mRNA in the rat brain and spinal cord

  title={Distribution of $\alpha$
 1a-, $\alpha$
 1b- and $\alpha$
 1d-adrenergic receptor mRNA in the rat brain and spinal cord},
  author={Heidi E. W. Day and Serge Campeau and Stanley J. Watson and Huda Akil},
  journal={Journal of Chemical Neuroanatomy},

Expression of α1b Adrenoceptor mRNA in Corticotropin-Releasing Hormone-Containing Cells of the Rat Hypothalamus and Its Regulation by Corticosterone

It is demonstrated, using dualin situ hybridization, that mRNA encoding α1b ADR is colocalized with CRH in the rat PVN and predicted that this receptor plays an important role in facilitation of the HPA axis response.

Expression of α(1)-adrenergic receptors in rat prefrontal cortex: cellular co-localization with 5-HT(2A) receptors.

Observations indicate that NE controls the activity of most PFC pyramidal neurons via α(1)ARs, either directly or indirectly, via GABAergic interneurons, and that atypical antipsychotics may exert a more powerful control of PFC function through the simultaneous blockade of α( 1) ARs and 5-HT(2A)Rs.

Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus

Differential expression of 5HT‐1A, α1b adrenergic, CRF‐R1, and CRF‐R2 receptor mRNA in serotonergic, γ‐aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus

The rostral‐caudal neurochemical distribution of three major cell groups, serotonin, γ‐aminobutyric acid (GABA), and catecholamine, and their relative colocalization with each other and mRNA encoding four different receptor subtypes that have been described to influence DR responses are described.

Role of supraspinal and spinal alpha1-adrenergic receptor subtypes in micturition reflex in conscious rats.

Noradrenergic projection from the brain stem to the lumbosacral spinal cord may promote the afferent limb rather than the efferent limb of the micturition reflex pathway via α(1A)-adren allergic receptors.



Cloning, expression, and tissue distribution of the rat homolog of the bovine alpha 1C-adrenergic receptor provide evidence for its classification as the alpha 1A subtype.

The cloned bovine alpha 1C-AR was the least sensitive of the three cloned subtypes to the alkylating effects of chloroethylclonidine but was the most sensitive to the prazosin analog SZL-49, properties also observed for the tissue alpha 1A subtype.

Distribution of alpha 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes

This differential distribution of adrenoceptors subtypes provides a framework for the functional diversity to the apparently widespread, diffuse, and rather homogeneous noradrenergic innervation of the CNS.

Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study

The present study justifies the pharmacological subclassification ofalpha‐2 receptors by providing anatomical evidence for specific and selective cell groups in the rat central nervous system containing mRNA for three alpha‐2 receptor subtypes.

Distribution of α1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with α1B and α1D

The distribution ofα1C-AR mRNA in rat tissues is compatible with the idea that the α1C corresponds to the classical native α1A-AR, and although many tissues contain all three α1-AR mRNAs, distinct tissue-specific expression is evident.

Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classification.

Re-evaluated the distribution of mRNA for the cloned alpha 1cAR subtype in various rat tissues thought to express alpha 1AR subtypes, as well as the human neuronal cell line SK-N-MC, suggesting that the clones may represent the pharmacological alpha 1AAR.

Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA.

A novel technique for identifying rare clones in a cDNA library is developed, which has been used successfully to isolate a c DNA clone encoding an alpha 1D-AR, which is classified as a novel alpha 1-AR subtype.

Noradrenergic alpha 1 and alpha 2 receptors: light microscopic autoradiographic localization.

  • W. YoungM. Kuhar
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1980
The observed codistribution of alpha 2 receptors with opiate receptors would provide an explanation of the observation that alpha 2 agonists block opiate withdrawal.