Distribution and therapeutic effect of intraarterially transferred tumor-infiltrating lymphocytes in hepatic malignancies. A preliminary report.

@article{Takayama1991DistributionAT,
  title={Distribution and therapeutic effect of intraarterially transferred tumor-infiltrating lymphocytes in hepatic malignancies. A preliminary report.},
  author={Tadatoshi Takayama and Masatoshi Makuuchi and Toshiyuki Sekine and Shoji Terui and Hiroshi Shiraiwa and Tomoo Kosuge and Shintaro Yamazaki and Hirokazu Hasegawa and Koyu Suzuki and Michiko Yamagata},
  journal={Cancer},
  year={1991},
  volume={68 11},
  pages={2391-6}
}
Indium-111-labeled tumor-infiltrating lymphocytes (111In-TIL) were transferred as an intrahepatic arterial bolus to determine their in vivo distribution in patients with hepatic malignancies. In the in vitro culture system, TIL were expanded upon simultaneous stimulation by recombinant interleukin-2 (rIL-2) and immobilized anti-CD3 monoclonal antibody. This double activation led not only to a larger cell yield, but also to a significantly more dominant subpopulation with CD4+ phenotype than… CONTINUE READING