Distribution and subcellular localization of high-molecular-weight microtubule-associated protein-2 expressing exon 8 in brain and spinal cord.

@article{ShafitZagardo1997DistributionAS,
  title={Distribution and subcellular localization of high-molecular-weight microtubule-associated protein-2 expressing exon 8 in brain and spinal cord.},
  author={Bridget Shafit-Zagardo and Nellie Kalcheva and Dennis W. Dickson and Peter Davies and Yvonne Kress},
  journal={Journal of neurochemistry},
  year={1997},
  volume={68 2},
  pages={862-73}
}
The expression of high-molecular-weight (HMW) microtubule-associated protein-2 (MAP-2) expressing exon 8 (MAP-2 + 8) was examined by immunoblotting during rat brain development and in sections of human CNS. In rat brain, HMW MAP-2 + 8 expression was detected at embryonic day 21 and increased during postnatal development. In adult rats, HMW MAP-2 + 8 comigrated with MAP-2a. In human adult brain, HMW MAP-2 + 8 was expressed in select neuronal populations, including pyramidal neurons of layers III… CONTINUE READING