Distribution and role of lipopolysaccharide in the pathogenesis of acute renal proximal tubule injury.

@article{Kang1995DistributionAR,
  title={Distribution and role of lipopolysaccharide in the pathogenesis of acute renal proximal tubule injury.},
  author={Yun Hee Kang and Michael C Falk and Timothy Brian Bentley and Chul Ho Lee},
  journal={Shock},
  year={1995},
  volume={4 6},
  pages={441-9}
}
Endotoxins (lipopolysaccharides; LPS) are known to cause multiple organ failure, including renal dysfunction. The present report elucidates LPS distribution and effect on renal proximal tubules in an attempt to gain a better understanding of the cellular mechanism underlying the pathogenesis of renal dysfunction in endotoxemia and sepsis. Rats were intravenously treated with biotin-linked or regular Escherichia coli (0111:B4) LPS (3 mg/kg) and sacrificed at different times. Kidneys were… CONTINUE READING

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