Distribution and regulation of renal ecto-5'-nucleotidase: implications for physiological functions of adenosine.

@article{Hir1993DistributionAR,
  title={Distribution and regulation of renal ecto-5'-nucleotidase: implications for physiological functions of adenosine.},
  author={M. Le Hir and B. Kaissling},
  journal={The American journal of physiology},
  year={1993},
  volume={264 3 Pt 2},
  pages={
          F377-87
        }
}
Adenosine exerts various effects via membrane receptors in the kidney. It reduces the glomerular filtration rate by altering the resistance of the glomerular arterioles, and it inhibits the release of renin as well as neurotransmission. Adenosine receptors have been further found at different levels of the nephron as well as in glomerular cells. Little is known concerning the mechanisms that regulate the extracellular concentration of adenosine, namely, its production, transport, and catabolism… Expand
Adenosine and kidney function.
Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation.
Role of the extracellular cAMP-adenosine pathway in renal physiology.
Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice.
Ecto-5'-nucleotidase (cd73)-dependent and -independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo.
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