Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases

@article{Koch1987DistributionAQ,
  title={Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases},
  author={Timothy R. Koch and PhD J. Aidan Carney and Liang W. Vay Go},
  journal={Digestive Diseases and Sciences},
  year={1987},
  volume={32},
  pages={369-376}
}
To study hyperplasia of peptidergic nerves purported to be diagnostic of Crohn's disease, we determined the distribution and concentrations of gut neuropeptides in specimens of normal intestine, ulcerative colitis, and Crohn's disease. Tissue specimens obtained at surgery were dissected into the mucosal-submucosal and muscularis externa layers, and immunoreactive gut neuropeptides were acid-extracted for measurement by radioimmunoassay. The immunoreactive species were characterized by column… CONTINUE READING

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