Distribution and properties of dihydrosphingosine-1-phosphate aldolase (sphinganine-1-phosphate alkanal-lyase).

  title={Distribution and properties of dihydrosphingosine-1-phosphate aldolase (sphinganine-1-phosphate alkanal-lyase).},
  author={W. Stoffel and D. Lekim and G. Sticht},
  journal={Hoppe-Seyler's Zeitschrift fur physiologische Chemie},
  volume={350 10},
Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease[S]
  • J. Saba
  • Chemistry, Medicine
  • Journal of Lipid Research
  • 2019
Sphingosine phosphate lyase (SPL) is the final enzyme in the sphingolipid degradative pathway, catalyzing the irreversible cleavage of long-chain base phosphates (LCBPs) to yield a long-chainExpand
Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome.
Gene therapy appears promising as a universal, potentially curative treatment for SPLIS, when Sgpl1 knockout mice that model SPLIS were treated with adeno-associated virus (AAV)-mediated SGPL1 gene therapy, they showed profound improvement in survival and kidney and neurological function compared to untreated SPLKO mice. Expand
Mitochondrial sphingosine-1-phosphate lyase is essential for phosphatidylethanolamine synthesis and survival of Trypanosoma brucei
It is shown that in the protozoan parasite Trypanosoma brucei, expression of TbSpl is essential for cell survival and link mitochondria to sphingolipid metabolism and suggest possible roles for PE in acidocalcisome function. Expand
S1P and Plasmalogen Derived Fatty Aldehydes in Cellular Signaling and Functions.
Investigations suggest a new role for long-chain fatty aldehydes as signaling lipids, ability to form adducts with GSH, proteins such as HDACs and regulate cellular functions. Expand
Sphingolipid biosynthesis in man and microbes
This review covers recent highlights from studies of the structures, mechanisms and inhibitors of key enzymes from the sphingolipid biosynthetic enzymes of prokaryotes and eukaryotes. Expand
S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling
Current evidence supporting the role of SPL in thymic egress, inflammation, and cancer is reviewed and recent progress in understanding other SPL functions, its role in inherited disease, and SPL targeting for therapeutic purposes is summarized. Expand
A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity.
Combined utilization of liquid chromatographic separation and multiple reaction monitoring-mass spectrometry allows for simultaneous quantification of the substrate S1P and product (2E)-hexadecenal and shows excellent sensitivity and specificity for sphingosine phosphate lyase activity detection. Expand
Characterisation of homologous sphingosine 1-phosphate lyase ( S 1 PL ) isoforms in the bacterial pathogen Burkholderia pseudomallei
1 EastChem School of Chemistry, David Brewster Road, The University of Edinburgh, Edinburgh, EH9 3FJ, UK. 2 Institute of Quantitative Biology, Biochemistry and Biotechnology, School of BiologicalExpand
Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei[S]
The pathogenic bacterium, Burkholderia pseudomallei K96243, encodes two homologous proteins that display moderate sequence identity to known eukaryotic and prokaryotic S1PLs, and the X-ray crystal structure of the PLP-bound form of S1 PL2021 is determined at 2.1 Å resolution revealing that the enzyme displays a conserved structural fold and active site architecture comparable with known S 1PLs. Expand