Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria.

@article{Lubelski2007DistributionAP,
  title={Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria.},
  author={Jacek Lubelski and Wil N. Konings and Arnold J M Driessen},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2007},
  volume={71 3},
  pages={
          463-76
        }
}
Membrane proteins responsible for the active efflux of structurally and functionally unrelated drugs were first characterized in higher eukaryotes. To date, a vast number of transporters contributing to multidrug resistance (MDR transporters) have been reported for a large variety of organisms. Predictions about the functions of genes in the growing number of sequenced genomes indicate that MDR transporters are ubiquitous in nature. The majority of described MDR transporters in bacteria use ion… CONTINUE READING

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