Distribution and paralogue specificity of mammalian deSUMOylating enzymes.

  title={Distribution and paralogue specificity of mammalian deSUMOylating enzymes.},
  author={Nagamalleswari Kolli and Jowita Mikolajczyk and Marcin Drąg and Debaditya Mukhopadhyay and Nela S Cintr{\'o}n Moffatt and Mary Dasso and Guy Salvesen and Keith D. Wilkinson},
  journal={The Biochemical journal},
  volume={430 2},
The covalent attachment of SUMO (small ubiquitin-like protein modifier) to target proteins results in modifications in their activity, binding interactions, localization or half-life. The reversal of this modification is catalysed by SENPs (SUMO-specific processing proteases). Mammals contain four SUMO paralogues and six SENP enzymes. In the present paper, we describe a systematic analysis of human SENPs, integrating estimates of relative selectivity for SUMO1 and SUMO2, and kinetic… CONTINUE READING
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