Distribution and modulation of the cellular receptor for transforming growth factor-beta

@article{Wakefield1987DistributionAM,
  title={Distribution and modulation of the cellular receptor for transforming growth factor-beta},
  author={Lalage M. Wakefield and Diana McLain Smith and Tohru Masui and Curtis C. Harris and Michael B. Sporn},
  journal={The Journal of Cell Biology},
  year={1987},
  volume={105},
  pages={965 - 975}
}
Scatchard analyses of the binding of transforming growth factor-beta (TGF-beta) to a wide variety of different cell types in culture revealed the universal presence of high affinity (Kd = 1-60 pM) receptors for TGF-beta on every cell type assayed, indicating a wide potential target range for TGF-beta action. There was a strong (r = +0.85) inverse relationship between the receptor affinity and the number of receptors expressed per cell, such that at low TGF-beta concentrations, essentially all… CONTINUE READING