Distribution and modulation of histamine H(3) receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease.

@article{Anichtchik2001DistributionAM,
  title={Distribution and modulation of histamine H(3) receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease.},
  author={Oleg V Anichtchik and Nina Peitsaro and Juha O. Rinne and Hannu O. Kalimo and Pertti Panula},
  journal={Neurobiology of disease},
  year={2001},
  volume={8 4},
  pages={707-16}
}
Parkinson's disease (PD) is a brain degenerative disorder with unknown etiology, and specific degeneration of mesencephalic dopaminergic cells is a morphological manifestation of the disease. The central histaminergic system appears to be activated in PD, since the histaminergic innervation is increased in the substantia nigra. The aim of the present study was to investigate the expression and function of histamine H(3) receptors in PD, using receptor mRNA in situ hybridization with… CONTINUE READING

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