Distribution and localization of p-hydroxy-d-amphetamine in rat brain.

@article{Jori1978DistributionAL,
  title={Distribution and localization of p-hydroxy-d-amphetamine in rat brain.},
  author={A. Jori and S. Caccia and G. Guiso and S. Garattini},
  journal={European journal of pharmacology},
  year={1978},
  volume={52 3-4},
  pages={
          361-5
        }
}
p-Hydroxy-d-amphetamine (p-OHdA) penetrates the blood--brain barrier poorly, when given acutely or by repeated systemic treatments, or when formed by biotransformation from administered d-amphetamine. However its distribution is relatively selective as it accumulates in the striatum more than in the brainstem. The rate of disappearance also differs in the two areas, being slower in the striatum than in the brainstem. These findings suggest that p-OHdA might be stored in different compartments… Expand
Role of training conditions in discrimination of central nervous system stimulants by rats

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