Distribution and kinetics of ethanol metabolism in rat brain.

  title={Distribution and kinetics of ethanol metabolism in rat brain.},
  author={Sergey Michailovich Zimatkin and Anton V Liopo and Richard A. Deitrich},
  journal={Alcoholism, clinical and experimental research},
  volume={22 8},
It was found that the accumulation of acetaldehyde produced from 50 mM ethanol in rat brain homogenates takes place in all major brain regions. The velocity varied between 3.5 to 7.1 nmol/mg of protein/hr. The rate increased in the following order: brain hemispheres, striatum, brainstem, hypothalamus, and cerebellum. Significant regional differences in this process were found: in the initial period of incubation (5 min), acetaldehyde accumulation was maximal in the brain hemispheres; but, in… CONTINUE READING

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