Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.

@article{MacNaughton2004DistributionAF,
  title={Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.},
  author={Wallace K MacNaughton and Marja D Van Sickle and Catherine M. Keenan and Kelly C. Cushing and Ken Mackie and Keith A Sharkey},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={286 5},
  pages={
          G863-71
        }
}
We investigated the distribution and function of cannabinoid (CB)(1) receptors in the submucosal plexus of the guinea pig ileum. CB(1) receptors were found on both types of submucosal secretomotor neurons, colocalizing with VIP and neuropeptide Y (NPY), the noncholinergic and cholinergic secretomotor neurons, respectively. CB(1) receptors colocalized with transient receptor potential vanilloid-1 receptors on paravascular nerves and fibers in the submucosal plexus. In the submucosal ganglia… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

Involvement of cannabinoid receptors in gut motility and visceral perception.

  • British journal of pharmacology
  • 2004
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation

  • Current neuropharmacology
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases.

  • Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • 2011
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2004
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The gastrointestinal pharmacology of cannabinoids: an update.

  • Current opinion in pharmacology
  • 2004
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES