Distribution and function of melanocortin receptors within the brain.

@article{Mountjoy2010DistributionAF,
  title={Distribution and function of melanocortin receptors within the brain.},
  author={Kathleen G. Mountjoy},
  journal={Advances in experimental medicine and biology},
  year={2010},
  volume={681},
  pages={29-48}
}
Biological responses to pro-opiomelanocortin (POMC)-derived peptides administered in the brain were documented in the 1950s but their molecular mechanisms of action only began to be resolved with the mapping of melanocortin receptor subtypes to specific brain regions in the 1990s. Out of the five melanocortin receptor subtypes, MC3R and MC4R are widely recognised as 'neural' melanocortin receptors. In situ hybridization anatomical mapping of these receptor subtypes to distinct hypothalamic… CONTINUE READING

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