Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition.

@article{Yano2003DistributionAF,
  title={Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition.},
  author={Seiichi Yano and Kaoru Kondo and Motonori Yamaguchi and Graham H. P. Richmond and Michael M. Hutchison and Alan E. Wakeling and Steven D. Averbuch and Peter F. Wadsworth},
  journal={Anticancer research},
  year={2003},
  volume={23 5A},
  pages={
          3639-50
        }
}
From immunohistochemical and ligand-binding studies, it is known that the epidermal growth factor receptor (EGFR), a member of the erbB family of receptors, is expressed in tissues of epithelial, mesenchymal and neuronal origin and plays a major role in normal cellular processes such as proliferation, differentiation and development. EGFR is highly expressed in a number of solid tumours and its expression correlates with tumour progression, resistance to chemotherapy and a poor prognosis; it is… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 80 CITATIONS, ESTIMATED 52% COVERAGE

Effects of edible bird's nest (EBN) on cultured rabbit corneal keratocytes

  • BMC complementary and alternative medicine
  • 2011
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Biologically active molecules that reduce polyglutamine aggregation and toxicity.

  • Human molecular genetics
  • 2006
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2004
2019

CITATION STATISTICS

  • 7 Highly Influenced Citations

  • Averaged 5 Citations per year over the last 3 years