Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

@inproceedings{Mercer2013DistributionAF,
  title={Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes},
  author={Robert R. Mercer and James F. Scabilloni and Ann F. Hubbs and Lori A. Battelli and Walter G McKinney and Sherri A Friend and Michael G. Wolfarth and Michael E. Andrew and Vincent Castranova and Dale W. Porter},
  booktitle={Particle and Fibre Toxicology},
  year={2013}
}
Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. To address the hypothesis that inhaled MWCNTs cause persistent morphologic changes, male C57BL/6 J mice were exposed in a whole-body inhalation system to a MWCNT aerosol and the fibrotic response in… CONTINUE READING
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