Distribution and excretion of artesunate in rats.

  title={Distribution and excretion of artesunate in rats.},
  author={K C Zhao and Z Y Song},
  journal={Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao},
  volume={4 4},
  • K C Zhao, Z Y Song
  • Published 1989 in
    Proceedings of the Chinese Academy of Medical…
The tissue distribution and excretion of artesunate in rats were determined using a radioimmunoassay method. Ten min after i.v. administration of the drug, the highest level was found in the intestine. Levels in other tissues were in the following decreasing order: brain, liver, kidney, testicle, muscle, fat, heart, serum, eyeball, spleen, and lung. However, 1 h after administration, the drug levels dropped significantly in all tissues, but not in the same proportions. High levels remained in… CONTINUE READING