• Corpus ID: 23376680

Distribution and excretion of 7-N-(p-hydroxyphenyl)-mitomycin C in normal mice.

@article{Imai1982DistributionAE,
  title={Distribution and excretion of 7-N-(p-hydroxyphenyl)-mitomycin C in normal mice.},
  author={Risa Imai and Makoto Morimoto and H Marumo},
  journal={Gan},
  year={1982},
  volume={73 4},
  pages={
          675-80
        }
}
Tissue distribution, excretion and stability of 7-N-(p-hydroxyphenyl)-mitomycin C (M-83) in normal mice were compared with those of mitomycin C (MMC) by microbiological assay. M-83 was more rapidly inactivated by mouse liver homogenate in vitro than MMC. MMC could not be detected by thin-layer chromatography-bioautography in the reaction mixture of M-83 incubated with mouse liver homogenate, or in the mouse urine. Both M-83 and MMC exhibited biphasic serum elimination characteristics after iv… 
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ANTITUMOR ACTIVITY AND PHARMACOKINETICS OF 7N-( p-HYDROXYPHENYL ) MITOMYCIN C IN HUMAN TUMOR XENOGRAFTS TRANSPLANTED INTO NUDE MICE
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In the tumor, the peak concentration and AUC600 detected by radioassay correlated well with the value of drug efficacy TRW/CRW, which was thought to be affected by inactivation of the agent in the tumor.
Antitumor activity and pharmacokinetics of 7-N-(p-hydroxyphenyl)mitomycin C in human tumor xenografts transplanted into nude mice.
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TLDR
In the tumor, the peak concentration and AUC60(0) detected by radioassay correlated well with the value of drug efficacy TRW/CRW, which was thought to be affected by inactivation of the agent in the tumor.
Comparative antitumor activities of 7-N-(p-hydroxyphenyl)mitomycin C (M-83) and mitomycin C.
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M-83 was markedly effective against solid tumors of sarcoma 180, Meth 1, Meth A and Lewis lung carcinoma, by a single intravenous injection and inhibited more strongly the incorporation of the radioactive precursor into DNA than that into RNA or protein at the concentration of 3 X 10(-3) mM.