Distribution and elimination characteristics of111In-DTPA-D-Phe1-octreotide and111In-DTPA-L-Phe1-octreotide in rats

Abstract

The present study compares distribution and elimination characteristics of111In-DTPA-D-Phe1-octreotide and111In-DTPA-L-Phe1 octreotide in rats and evaluated the effect of the replacement of the terminal L-phenylalanine by D-phenylalanine on pharmacokinetic profiles of the radiolabelled peptides. Both agents exhibited rapid radioactivity clearance from the… (More)
DOI: 10.1007/BF03190403

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@article{Lznkov2002DistributionAE, title={Distribution and elimination characteristics of111In-DTPA-D-Phe1-octreotide and111In-DTPA-L-Phe1-octreotide in rats}, author={Alice L{\'a}zn{\'i}{\vc}kov{\'a} and Milan L{\'a}zn{\'i}{\vc}ek and Franti{\vs}ek Trejtnar and Ludmila Melicharov{\'a} and Kazuko Horuichi Suzuki and Hiromichi Akizawa and Yasushi Arano and Akira Yokoyama}, journal={European Journal of Drug Metabolism and Pharmacokinetics}, year={2002}, volume={27}, pages={37-43} }