Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer.

@article{Davies2004DistributionAC,
  title={Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer.},
  author={E. J. Davies and Fiona Blackhall and Jonathan H. Shanks and Guido David and Alan T. McGown and Ric Swindell and Richard J. Slade and Pierre Leonard Martin-Hirsch and John Thomas Gallagher and Gordon C. Jayson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 15},
  pages={5178-86}
}
PURPOSE Heparan sulfate proteoglycans have been implicated in cancer cell growth, invasion, metastasis, and angiogenesis. This study was designed to compare their expression in normal ovary and ovarian tumors and then to examine their prognostic significance in ovarian cancer. EXPERIMENTAL DESIGN The expression of syndecan-1, -2, -3, and -4, glypican-1, and perlecan was assessed by immunohistochemistry in 147 biopsies that included normal ovary and benign, borderline, and malignant ovarian… CONTINUE READING

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