Distribution and biological activities of the flavonoid luteolin.

@article{LpezLzaro2009DistributionAB,
  title={Distribution and biological activities of the flavonoid luteolin.},
  author={Miguel L{\'o}pez-L{\'a}zaro},
  journal={Mini reviews in medicinal chemistry},
  year={2009},
  volume={9 1},
  pages={
          31-59
        }
}
Epidemiological evidence suggests that flavonoids may play an important role in the decreased risk of chronic diseases associated with a diet rich in plant-derived foods. Flavonoids are also common constituents of plants used in traditional medicine to treat a wide range of diseases. The purpose of this article is to summarize the distribution and biological activities of one of the most common flavonoids: luteolin. This flavonoid and its glycosides are widely distributed in the plant kingdom… Expand
A review on the dietary flavonoid kaempferol.
TLDR
The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases. Expand
Citrus Flavones: An Update on Sources, Biological Functions, and Health Promoting Properties
TLDR
This review analyzes the biochemical, pharmacological, and biological properties of Citrus flavones, emphasizing their occurrence in Citrus spp. Expand
Chemistry and Biological Activities of Flavonoids: An Overview
TLDR
The structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production are highlighted. Expand
The potential role of dietary plant ingredients against mammary cancer: a comprehensive review.
TLDR
The potent role of various plant-based phytochemicals as potential therapeutic agents in the treatment or prevention of breast cancer along with the proposed mechanisms of action are discussed. Expand
A quest for staunch effects of flavonoids: Utopian protection against hepatic ailments
Abstract The role of flavonoids as the major red, blue and purple pigments in plants has gained these secondary products a great deal of attention over the years. Flavonoids are polyphenols and occurExpand
BIOLOGICAL ACTIVITIES OF FLAVONOIDS: AN OVERVIEW
Background: Plants and herbs consumed by humans are the rich sources of phytonutrients compounds synthesized in plants itself. Such bioactive substances are responsible for the plant’s antioxidantExpand
Molecular Structure, Biological Functions, and Metabolic Regulation of Flavonoids
TLDR
Flavonoids exhibit a wide range of biological effects such as antibacterial, antiviral, antifungal, antiosteoporotic, antitumor, antithrombogenic, anti-inflammation, antiatherosclerotic, and antihepatotoxic activities. Expand
Flavonoids: an overview
TLDR
Current trends of research and development activities on flavonoid relate to isolation, identification, characterisation and functions of flavonoids and finally their applications on health benefits and future research directions are discussed. Expand
Role of microRNAs in the anticancer effects of the flavonoid luteolin: a systematic review
TLDR
The role of miRNAs in the luteolin effects on different cancers is discussed, which can be in line with the studies, which have shown that mi RNAs may be potential therapeutic targets in cancer treatment. Expand
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits
TLDR
This review is aimed at providing an extensive overview on the in vivo pharmacological action of luteolin and at stressing the main features related to its bioavailability, absorption, and metabolism, while essential steps determine its absolute health benefits and safety profiles. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 510 REFERENCES
Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis.
TLDR
The wider distribution and the more abundant presence of flavonoids in the plant kingdom, together with the present results, suggest that flavonoid may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumors. Expand
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.
TLDR
Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing. Expand
Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity*
TLDR
The findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their FAS inhibitory properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and antineoplastic effects. Expand
Antimicrobial activity of flavonoids
TLDR
Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents. Expand
Flavonoids as antioxidants.
  • P. Pietta
  • Chemistry, Medicine
  • Journal of natural products
  • 2000
TLDR
This review presents the current knowledge on structural aspects and in vitro antioxidant capacity of most common flavonoids as well as in vivo antioxidant activity and effects on endogenous antioxidants. Expand
Anti-inflammatory plant flavonoids and cellular action mechanisms.
TLDR
The effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes are summarized and a potential for new anti-inflammatory agents are discussed. Expand
Flavonoids: Promising anticancer agents
TLDR
Results from laboratory studies, epidemiological investigations, and human clinical trials indicate that flavonoids have important effects on cancer chemoprevention and chemotherapy. Expand
Evaluation of the anti-inflammatory activity of luteolin in experimental animal models.
TLDR
The results derived from the whole blood assay for cyclooxygenase (COX) and the reverse transcription-polymerase chain reaction (RT-PCR) assay indicate that luteolin may be a potent selective inhibitor of cyclo oxygengenase-2 (COx-2) and that the inhibition is attributable to its down-regulation of the mRNA expression of COX-2 in inflammatory responses. Expand
Cancer preventive effects of flavonoids—a review
TLDR
This review focuses on the biological effects of the main flavonoids, as well as the epidemiologic evidence that support their potential cancer protective properties. Expand
Luteolin, an Abundant Dietary Component is a Potent Anti-leishmanial Agent that Acts by Inducing Topoisomerase II-mediated Kinetoplast DNA Cleavage Leading to Apoptosis
TLDR
Luteolin has great promise for acting as a lead compound in the chemotherapy of leishmaniasis, a major concern in developing countries, and can be a strong candidate for antileishmanial drug design. Expand
...
1
2
3
4
5
...