Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

@article{Logan1996DistributionVR,
  title={Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data},
  author={J. Logan and J. Fowler and N. Volkow and G. Wang and Y. Ding and D. Alexoff},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={1996},
  volume={16},
  pages={834 - 840}
}
  • J. Logan, J. Fowler, +3 authors D. Alexoff
  • Published 1996
  • Mathematics, Chemistry, Medicine
  • Journal of Cerebral Blood Flow & Metabolism
  • The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely used as a model parameter in imaging studies. The DVR corresponds to the ratio of the DV of a receptor-containing region to a nonreceptor region and generally requires the measurement of an arterial input function. Here we propose a graphical method for determining the DVR that does not require blood sampling. This method uses data from a nonreceptor region with an average tissue-to-plasma efflux… CONTINUE READING
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    References

    SHOWING 1-10 OF 23 REFERENCES
    Effects of Blood Flow on [11C]Raclopride Binding in the Brain: Model Simulations and Kinetic Analysis of PET Data
    • J. Logan, N. Volkow, +9 authors S. Vitkun
    • Chemistry, Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 1994
    • 158
    Differentiation of Radioligand Delivery and Binding in the Brain: Validation of a Two-Compartment Model for [11C]Flumazenil
    • 110
    Comparison of Methods for Analysis of Clinical [11C]Raclopride Studies
    • A. Lammertsma, C. Bench, +4 authors R. Frackowiak
    • Chemistry, Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 1996
    • 475
    Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations
    • C. Patlak, R. Blasberg
    • Mathematics, Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 1985
    • 1,492
    • PDF
    Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
    • J. Logan, J. Fowler, +8 authors D. Christman
    • Chemistry, Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 1990
    • 1,256
    • PDF
    Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography
    • R. Carson, M. Channing, +4 authors P. Herscovitch
    • Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 1993
    • 337
    • PDF
    Compartmental Analysis of [11C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography
    • 342
    A new PET ligand for the dopamine transporter: studies in the human brain.
    • N. Volkow, Y. Ding, +5 authors N. Pappas
    • Chemistry, Medicine
    • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    • 1995
    • 102
    SPECT imaging of dopamine D2 receptors with 2'-iodospiperone.
    • 5
    Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography.
    • L. Farde, E. Ehrin, +5 authors G. Sedvall
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1985
    • 292
    • PDF