Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

@article{Logan1996DistributionVR,
  title={Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data},
  author={Jean Logan and Joanna S. Fowler and Nora D. Volkow and Gene-Jack Wang and Yu-Shin Ding and David L. Alexoff},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={1996},
  volume={16},
  pages={834 - 840}
}
The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely used as a model parameter in imaging studies. The DVR corresponds to the ratio of the DV of a receptor-containing region to a nonreceptor region and generally requires the measurement of an arterial input function. Here we propose a graphical method for determining the DVR that does not require blood sampling. This method uses data from a nonreceptor region with an average tissue-to-plasma efflux… 
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