• DOI:10.1097/00004647-199609000-00008
Corpus ID: 41398196

Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

@article{Logan1996DistributionVR,
  title={Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data},
  author={J. Logan and J. Fowler and N. Volkow and G. Wang and Y. Ding and D. Alexoff},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={1996},
  volume={16},
  pages={834 - 840}
}

J. Logan, J. Fowler, +3 authors D. Alexoff

Published 1996

Mathematics, Chemistry, Medicine

Journal of Cerebral Blood Flow & Metabolism

The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely used as a model parameter in imaging studies. The DVR corresponds to the ratio of the DV of a receptor-containing region to a nonreceptor region and generally requires the measurement of an arterial input function. Here we propose a graphical method for determining the DVR that does not require blood sampling. This method uses data from a nonreceptor region with an average tissue-to-plasma efflux… CONTINUE READING

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