Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
@article{Logan1996DistributionVR, title={Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data}, author={J. Logan and J. Fowler and N. Volkow and G. Wang and Y. Ding and D. Alexoff}, journal={Journal of Cerebral Blood Flow & Metabolism}, year={1996}, volume={16}, pages={834 - 840} }
The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely used as a model parameter in imaging studies. The DVR corresponds to the ratio of the DV of a receptor-containing region to a nonreceptor region and generally requires the measurement of an arterial input function. Here we propose a graphical method for determining the DVR that does not require blood sampling. This method uses data from a nonreceptor region with an average tissue-to-plasma efflux… CONTINUE READING
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