Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

@article{Weber2007DistributionSP,
  title={Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome},
  author={M. Weber and I. Hellmann and M. Stadler and L. Ramos and S. P{\"a}{\"a}bo and M. Rebhan and D. Sch{\"u}beler},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={457-466}
}
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact on gene expression, we measured methylation, RNA polymerase occupancy and histone modifications at 16,000 promoters in primary human somatic and germline cells. We find CpG-poor promoters hypermethylated in somatic cells, which does not preclude their activity. This methylation is present in male gametes and results in evolutionary loss of CpG dinucleotides, as measured by divergence between humans and… Expand
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