Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

  title={Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain},
  author={Junjie U Guo and Yijing Su and Joo Heon Shin and Jaehoon Shin and Hongda Li and Bin Xie and Chun Zhong and Shaohui Hu and Thuc M. Le and Guoping Fan and H. A. Zhu and Qiang Chang and Yuan Gao and Guoli Ming and Hongjun Song},
  booktitle={Nature Neuroscience},
DNA methylation has critical roles in the nervous system and has been traditionally considered to be restricted to CpG dinucleotides in metazoan genomes. Here we show that the single base–resolution DNA methylome from adult mouse dentate neurons consists of both CpG (∼75%) and CpH (∼25%) methylation (H = A/C/T). Neuronal CpH methylation is conserved in human brains, enriched in regions of low CpG density, depleted at protein-DNA interaction sites and anticorrelated with gene expression… CONTINUE READING
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