Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus

@article{Baker1991DistributionMA,
  title={Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus},
  author={Kerry G. Baker and Glenda M. Halliday and Jean-Pierre Hornung and Laurence Basil Geffen and Richard G. H. Cotton and Istvan To¨rk},
  journal={Neuroscience},
  year={1991},
  volume={42},
  pages={757-775}
}

Anatomical distribution of serotonin‐containing neurons and axons in the central nervous system of the cat

TLDR
Using a monoclonal antibody to serotonin (5‐HT) was undertaken to provide a comprehensive description of the 5‐HT‐containing neurons and of the distribution of their axonal processes in the cat brain and spinal cord, indicative of the multiple possible actions of serotonin in the central nervous system.

Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain

TLDR
The apparently low numbers of coexisting messengers in mouse serotonin neurons, compared to rat, indicate considerable species differences with regard to the chemical neuronatomy of the DRN, and extrapolation of DRN physiology, and possibly pathology, from rat to mouse, and even human, should be made with caution.

Brain stem serotonin-synthesizing neurons in Alzheimer's disease: a clinicopathological correlation

TLDR
There was a trend for the raphe pathology to correlate with the age of onset and duration of dementia and the Blessed dementia score in AD+ patients, indicating that inAD+ patients the serotonin-synthesizing neurons were selectively affected.

Anatomy of the Serotonergic System a

  • I. Törk
  • Biology
    Annals of the New York Academy of Sciences
  • 1990
TLDR
The serotonergic (5-hydroxytryptaminergic, 5-HT) system is one of the diffusively organized projection systems of the brain and the full description of its neuronal localization and projections has only become possible with the availability of the histoflu~rescence’ and immunohistochemical techniques.

Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus

TLDR
In both rat and mouse DRN, a subpopulation of 5‐HT neurons is endowed withNK1r receptors and may be directly involved in the antidepressant‐like effects of NK1r antagonists, representing a new element in the neuronal circuitry currently proposed to account for the role of SP in mood regulation.
...

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The present findings demonstrate the presence of two putative transmitters, a biogenic amine and a polypeptide, within the same neuron in the mammalian central nervous system.

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A detailed statistical analysis of silver grain distribution in both labeled and “unlabeled” nerve cell bodies indicated that in the former, but not in the latter, dense bodies had a relatively high affinity for [3H]5‐HT.

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