Distribution, localization, and pulmonary effects of yttrium chloride following intratracheal instillation into the rat.

@article{Hirano1990DistributionLA,
  title={Distribution, localization, and pulmonary effects of yttrium chloride following intratracheal instillation into the rat.},
  author={Seishiro Hirano and Naomi Kodama and Katsuhiro Shibata and Kazuo T. Suzuki},
  journal={Toxicology and applied pharmacology},
  year={1990},
  volume={104 2},
  pages={
          301-11
        }
}
Metabolic behavior and pulmonary toxicity of yttrium chloride (YCl3) deposited in the lung was investigated. Yttrium chloride was instilled intratracheally into rats and the time-course and dose-related changes in distribution of Y between lung tissue and bronchoalveolar lavage fluid (BALF) and pulmonary inflammatory responses were investigated. Pulmonary clearance of Y was very slow and the half-life was estimated to be 168 days. Yttrium content in the supernatant of BALF did not exceed 5… CONTINUE READING
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