Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study.

@article{Laurent2011DistributionFA,
  title={Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study.},
  author={C Laurent and Sabina Mueller and Catherine Do and Talal Al-Saati and Sophie Allart and Luigi Maria Larocca and Stefan Hohaus and Sophie Duchez and Anne Quillet-Mary and Guy Laurent and P. Brousset and Salvatore Valitutti},
  journal={Blood},
  year={2011},
  volume={118 20},
  pages={5371-9}
}
CD8+ CTLs are thought to play a role in the control of follicular lymphoma (FL). Yet, the link between CTL tissue distribution, activation status, ability to kill FL cells in vivo, and disease progression is still elusive. Pretreatment lymph nodes from FL patients were analyzed by IHC (n = 80) or by 3-color confocal microscopy (n = 10). IHC revealed a rich infiltrate of CD8+ granzyme B+ (GrzB) cells in FL interfollicular spaces. Accordingly, confocal microscopy showed an increased number of CD3… CONTINUE READING