Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats.

@article{Yokel2012DistributionEA,
  title={Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats.},
  author={Robert A. Yokel and Tu C Au and Robert C. Macphail and Sarita S. Hardas and David Butterfield and Rukhsana Sultana and Michael Wayne Goodman and Michael T. Tseng and Mo Dan and Hamed Haghnazar and Jason M Unrine and Uschi M. Graham and Peng Wu and Eric A. Grulke},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={127 1},
  pages={256-68}
}
Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture, and is being pursued as an antioxidant therapeutic. Our objective is to extend previous findings showing that there were no reductions of cerium in organs of the mononuclear phagocyte (reticuloendothelial) system up to 30 days after a single nanoscale ceria administration. An ~5% aqueous dispersion of citrate-stabilized 30 nm ceria, synthesized and characterized in-house, or vehicle, was iv infused… CONTINUE READING
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Hepatic structural and oxidative stress indices alteration by intravenous infusion of nanoceria

  • M. T. Tseng, X. Lu, +7 authors E Grulke
  • Toxicol. Appl. Pharmacol
  • 2012
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