Distortion of the active site of chymotrypsin complexed with a serpin.

@article{Plotnick1996DistortionOT,
  title={Distortion of the active site of chymotrypsin complexed with a serpin.},
  author={Michael I. Plotnick and Leland Mayne and Norman M. Schechter and Harvey Rubin},
  journal={Biochemistry},
  year={1996},
  volume={35 23},
  pages={7586-90}
}
There is no complete understanding of how serine protease inhibitors of the serpin family inhibit their target enzymes. Structural and biochemical studies have suggested that serpins utilize a mechanism that is distinct from the standard mechanism of inhibition proposed for most small protein protease inhibitors. Proton nuclear magnetic resonance… CONTINUE READING