Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts.

Abstract

Interstrand cross-links (ICLs) are formed by many chemotherapeutic agents and may also arise endogenously. The mechanisms used to repair these lesions remain unclear in mammalian cells. Repair in Escherichia coli and Saccharomyces cerevisiae requires an initial unhooking step to release the tethered DNA strands. We used a panel of linear substrates… (More)
DOI: 10.1021/bi800925e

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