Distorted relation between mRNA copy number and corresponding major histocompatibility complex ligand density on the cell surface.

@article{Weinzierl2007DistortedRB,
  title={Distorted relation between mRNA copy number and corresponding major histocompatibility complex ligand density on the cell surface.},
  author={Andreas Oliver Weinzierl and Claudia Lemmel and Oliver Schoor and Margret Mueller and Tobias Krueger and Dorothee Wernet and Joerg Hennenlotter and Arnulf Stenzl and Karin Klingel and Hans-Georg Rammensee and Stefan Stevanovi{\'c}},
  journal={Molecular & cellular proteomics : MCP},
  year={2007},
  volume={6 1},
  pages={102-13}
}
The major histocompatibility complex (MHC) presents peptides derived from degraded cellular proteins to T-cells and is thus crucial for triggering specific immune responses against viral infections or cancer. Up to now, there has been no evidence for a correlation between levels of mRNA (the "transcriptome") and the density of MHC-peptide complexes (the "MHC ligandome") on cells. Because such dependences are of intrinsic importance for the detailed understanding of translation efficiency and… CONTINUE READING
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