Distinguishing single- and double-stranded nucleic acid molecules using solid-state nanopores.

@article{Skinner2009DistinguishingSA,
  title={Distinguishing single- and double-stranded nucleic acid molecules using solid-state nanopores.},
  author={Gary M. Skinner and Michiel van den Hout and Onno D Broekmans and Cees Dekker and Nynke H Dekker},
  journal={Nano letters},
  year={2009},
  volume={9 8},
  pages={
          2953-60
        }
}
Solid-state nanopores offer a promising method for rapidly probing the structural properties of biopolymers such as DNA and RNA. We have for the first time translocated RNA molecules through solid-state nanopores, comparing the signatures of translocating double-stranded RNA molecules and of single-stranded homopolymers poly(A), poly(U), poly(C). On the basis of their differential blockade currents, we can rapidly discriminate between both single- and double-stranded nucleic-acid molecules, as… CONTINUE READING

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